货号
产品规格
售价
备注
BN40219R-100ul
100ul
¥2120.00
交叉反应（总）:Human,Mouse,Rat,Cow,;推荐应用:WB,
BN40219R-200ul
200ul
¥3140.00
交叉反应（总）:Human,Mouse,Rat,Cow,;推荐应用:WB,
产品描述
| 英文名称 | Fibulin 5 |
| 中文名称 | 衰老关键蛋白抗体 |
| 别 名 | ARMD3; Dance; Developmental arteries and neural crest EGF like protein; FBLN5; FIBL 5; Developmental arteries and neural crest EGF-like protein; EVEC; Fbln5; FBLN5_HUMAN; UP50; FIBL 5; FIBL-5; Fibulin-5; FLJ90059; Urine p50 protein. |
| 研究领域 | 心血管 免疫学 信号转导 内分泌病 细胞骨架 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, (predicted: Mouse, Rat, Cow, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Fibulin 5:101-200/448 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | |
| 产品介绍 | Fibulin 5: A protein that belongs to a family of extracellular proteins expressed in the basement membranes of blood vessels. Fibulin 5 may be essential for the polymerization of elastin. Missense mutations in FBLN5, the gene that encodes fibulin 5, appear responsible for 1-2% of cases of age-related macular degeneration (AMD). FBLN5 is located on chromosome 14 in band 14q32.1. See also: Fibulin 3. May play a role in vascular growth and maturation during development and in lesions of injured vessels. Function: Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling. Subunit: Homodimer. Subcellular Location: Secreted. Tissue Specificity: Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes. DISEASE: Cutis laxa, autosomal dominant, 2 (ADCL2) [MIM:614434]: A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. Note=The disease is caused by mutations affecting the gene represented in this entry. Cutis laxa, autosomal recessive, 1A (ARCL1A) [MIM:219100]: A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. The clinical spectrum of autosomal recessive cutis laxa is highly heterogeneous with respect to organ involvement and severity. Type I autosomal recessive cutis laxa is a specific, life-threatening disorder with organ involvement, lung atelectasis and emphysema, diverticula of the gastrointestinal and genitourinary systems, and vascular anomalies. Associated cranial anomalies, late closure of the fontanel, joint laxity, hip dislocation, and inguinal hernia have been observed but are uncommon. Note=The disease is caused by mutations affecting the gene represented in this entry. Age-related macular degeneration 3 (ARMD3) [MIM:608895]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Similarity: Belongs to the fibulin family. Contains 6 EGF-like domains. SWISS: Q9UBX5 Gene ID: 10516 Database links: Human Mouse Human Human Mouse Human Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Fibulin-5 Fibulin-5亦称为FBLN-5、DANCE或EVEC是细胞外基质蛋白质家族的一员，在组织器官发育、重塑和修复过程中起重要作用，并与内皮细胞相互作用.Fibulin-5广泛分布于富含弹性蛋白的组织, 能直接与原弹性蛋白结合,并将后者锚于细胞表面,这对形成弹性纤维十分关键, 对血管的发育和修复具有重要作用.此外,Fibuljn-5还能促进创口愈合, 与细胞的增殖、运动和侵袭有关 fibulin-5有学者称“皮肤衰老关键蛋白”与皮肤弹性有关的蛋白，对于起着固定细胞外壁、保持肌肤紧绷、维护肺部和血管柔韧性作用的弹性纤维的发育十分关键. 还有学者认为：fibulin-5能够抑制血管的形成，该蛋白质在肿瘤转移过程中表达降低或消失，将有可能用于肿瘤治疗方面的研究。 |
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